|
Malignant neoplasm of ovary
|
0.700 |
CausalMutation
|
disease |
CGI |
|
|
|
|
Malignant neoplasm of ovary
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
We conclude that the association of GSTM1 null/GSTTl null with survival appears to be mediated through different mechanisms to p53 expression in ovarian cancer and in addition, may be a better predictor of outcome.
|
11328408 |
2001 |
|
Malignant neoplasm of ovary
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
We conducted a retrospective immunohistochemical evaluation of the prognostic significance of the expression of p53 and the related proteins Bax, Bcl-2, growth arrest and DNA damage (Gadd45), murine double minute 2 (Mdm2) and p21(WAF1/CIP1) in chemonaive tumours taken from 66 patients with ovarian cancer.
|
11094305 |
2000 |
|
Malignant neoplasm of ovary
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
In our present study, we examined EphA2 and p53 status (both expression and full-length mutation status) in 6 ovarian cell lines and 79 human ovarian cancers to determine potential associations.
|
16969087 |
2006 |
|
Malignant neoplasm of ovary
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
We evaluated the association between lifestyle and reproductive factors and risk of ovarian cancer defined by p53 and MAPK expression.<b>Methods:</b> Epithelial ovarian cancer cases (<i>n</i> = 274) and controls (<i>n</i> = 1,907) were identified from the Nurses' Health Study and Nurses' Health Study II prospective cohorts, and the population-based New England Case-Control study.
|
29133366 |
2018 |
|
Malignant neoplasm of ovary
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
DNA ploidy and MYC DNA amplification in ovarian carcinomas. Correlation with p53 and bcl-2 expression, proliferative activity and prognosis.
|
8972757 |
1996 |
|
Malignant neoplasm of ovary
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
In breast cancer, by contrast with colorectal, lung and ovarian cancer, there appears to be no clear association between p53 DNA abnormalities and p53 expression.
|
1537617 |
1992 |
|
Malignant neoplasm of ovary
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Therefore the expression of p53 and p21WAF1 was assessed immunohistochemically in a series of 50 ovarian carcinomas considering clinicopathological variables.
|
12375014 |
2003 |
|
Malignant neoplasm of ovary
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Knowing that p53 expression status is used for chemotherapeutic approaches and prognosis in ovarian cancer, the results obtained highlight the importance of locating TP53 mutations.
|
29422776 |
2018 |
|
Malignant neoplasm of ovary
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
There was no significant difference between BRCA1-linked ovarian cancers and their sporadic counterparts with regard to p53 protein expression (P = 0.5).
|
15581943 |
2004 |
|
Malignant neoplasm of ovary
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
The demonstration that p53 binds directly to the PIK3CA promoter and inhibits its activity identifies a novel mechanism whereby these two mediators regulate cellular functions, and whereby inactivation of p53 and subsequent upregulation of PIK3CA might contribute to the pathophysiology of ovarian cancer.
|
18270270 |
2008 |
|
Malignant neoplasm of ovary
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Tissue p53 expression may be of prognostic value in women with OC.
|
18452430 |
2008 |
|
Malignant neoplasm of ovary
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Thus, our results suggest that histological tumour type and grade are major determinants of spontaneous apoptosis in ovarian carcinomas; p53 alterations do not adversely but rather positively affect spontaneous apoptosis by increasing growth fraction.
|
10682669 |
2000 |
|
Malignant neoplasm of ovary
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, these data suggest that at least in our patient cohort p53 and p73 expression levels are not correlated to malignant progression of ovarian cancer.
|
18039564 |
2008 |
|
Malignant neoplasm of ovary
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
There was a significant correlation between the presence of anti-p53 antibody and tissue overexpression of p53 in ovarian cancers.
|
11275794 |
2001 |
|
Malignant neoplasm of ovary
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
We further investigated the expression and mutation of Tp53 and associated markers such as p21 and HDM2 in ovarian cancer.
|
19375154 |
2009 |
|
Malignant neoplasm of ovary
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that activation of TP53 may provide a promising new therapy for managing low-grade ovarian cancer and other cancers in humans in which wild-type TP53 is expressed.
|
22396451 |
2012 |
|
Malignant neoplasm of ovary
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Therefore, we conclude that CR389 is a candidate therapeutic agent for the treatment of human ovarian cancer via the activation of p53.
|
25639717 |
2015 |
|
Malignant neoplasm of ovary
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Co-immunoprecipitation and western blotting showed significantly lower levels of p53 and p53 Ser15-pho in the miR-17 transfected OCCs as compared to the mutant miR-17 transfected OCCs.
|
25510663 |
2015 |
|
Malignant neoplasm of ovary
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Malignant tumors derived from these organs maintained the pattern of p53 expression with ovarian cancers (n = 14, median: 0.84 ng/mg) exceeding all other tissue types examined.
|
10754462 |
2000 |
|
Malignant neoplasm of ovary
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Patients with concomitantly high levels of PARP, FANCD2 and P53 protein expression are at increased risk of early ovarian cancer recurrence and platinum resistance.
|
22253870 |
2012 |
|
Malignant neoplasm of ovary
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
The differences in miR-7 expression depending on TP53 status found in clinical OC samples were not observed in OC cell lines. miR-7 overexpression correlated with diminished BCL2 expression, but there was no relationship between miR-7 and EGFR expression, neither in tumour samples nor in the cell lines.
|
25862909 |
2015 |
|
Malignant neoplasm of ovary
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Pelvic and extrapelvic OVCA implants demonstrated similar patterns of signaling pathway expression and identical p53 mutations.
|
23933223 |
2013 |
|
Malignant neoplasm of ovary
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
The icaritin-induced OC cell apoptosis may be associated with the activation of p53 and the suppression of Akt/mTOR pathway.
|
29625193 |
2018 |
|
Malignant neoplasm of ovary
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that COX-2 expression might play an important role in ovarian cancer development and that COX-2 expression in ovarian adenocarcinomas is frequently associated with p53 protein accumulation.
|
12469191 |
2003 |